This issue of Otolaryngologic Clinics, Guest Edited by Drs. Melissa A. Pynnonen and Cecelia E. Schmalbach, is devoted to Office-Based Surgery in Otolaryngology. Articles in this important issue include: Introduction to Office-Based Surgery in Otolaryngology; Office-based Cosmetic Procedures in Otolaryngology; Mohs Reconstruction and Scar Revision; Office-based Sinus Procedures; In-office Functional Nasal Surgery; Office-based Otology Procedures; In-office Eustachian Tuboplasty; In-office Laryngology Injectables; Office-based Management of Laryngeal Neoplasms; Ultrasound of the Thyroid and Neck; In-office Evaluation and Management of Dysphagia; Patient Safety and Regulatory Considerations; Instrument Sterilization in Otolaryngology; and Facility Accreditation and Coding for Otolaryngology Office Procedures.