Epidemiology of Lumbar Intervertebral Disc Degeneration, Structure and Biology of the Intervertebral Disc in Health and Disease, Nutrition of the Intervertebral Disc, The Endplate and Its Relevance with Intervertebral Disc Degeneration, Genetic Risk Factors in Intervertebral Disc Degeneration, Biomechanics of Intervertebral Disc Degeneration, Diagnostic Tools and Imaging Methods in Intervertebral Disc Degeneration, An Overview of the Management of Degenerative Disc Disease, Adjacent Level Disc Disease - Is it Really a Fusion Disease? Prosthetic Total Disc Replacement, Stem Cell Regeneration of the Intervertebral Disc, Gene Therapy for Intervertebral Disc Degeneration, Tissue Engineering for Intervertebral Disc Degeneration, Emerging Technologies for Molecular Therapy for Intervertebral Disc Degeneration, Intervertebral Disc Transplantation